| 2018 |
| 09/26 | 1,754 | 1,786 | 1,740 | 1,786 | +1.3% | 96,500 | 1014億6997万 | +11.63% |
| 09/25 | 1,724 | 1,764 | 1,712 | 1,763 | +2.26% | 160,600 | 1001億6324万 | +11.02% |
| 09/21 | 1,703 | 1,724 | 1,685 | 1,724 | +2.13% | 121,300 | 979億4749万 | +9.25% |
| 09/20 | 1,710 | 1,710 | 1,676 | 1,688 | -0.76% | 93,600 | 959億218万 | +7.72% |
| 09/19 | 1,654 | 1,705 | 1,652 | 1,701 | +3.4% | 179,200 | 966億4077万 | +9.04% |
| 09/18 | 1,622 | 1,648 | 1,602 | 1,645 | +1.42% | 85,500 | 934億5918万 | +5.92% |
| 09/14 | 1,622 | 1,630 | 1,609 | 1,622 | +1.38% | 115,800 | 921億5245万 | +4.85% |
| 09/13 | 1,595 | 1,610 | 1,589 | 1,600 | +0.76% | 62,400 | 909億254万 | +3.63% |
| 09/12 | 1,610 | 1,610 | 1,566 | 1,588 | -0.87% | 77,400 | 902億2077万 | +2.98% |
| 09/11 | 1,604 | 1,608 | 1,581 | 1,602 | 0% | 57,900 | 910億1617万 | +3.96% |
| 09/10 | 1,570 | 1,638 | 1,570 | 1,602 | +2.23% | 142,800 | 910億1617万 | +4.03% |
| 09/07 | 1,563 | 1,576 | 1,543 | 1,567 | -0.57% | 77,400 | 890億2768万 | +1.89% |
| 09/06 | 1,579 | 1,600 | 1,567 | 1,576 | -0.38% | 81,900 | 895億3901万 | +2.47% |
| 09/05 | 1,575 | 1,600 | 1,573 | 1,582 | +0.51% | 85,200 | 898億7989万 | +2.93% |
| 09/04 | 1,569 | 1,585 | 1,551 | 1,574 | +0.58% | 54,000 | 894億2538万 | +2.27% |
| 09/03 | 1,571 | 1,575 | 1,555 | 1,565 | -0.06% | 45,600 | 889億1405万 | +1.82% |
| 08/31 | 1,542 | 1,579 | 1,541 | 1,566 | 0% | 47,300 | 889億7086万 | +1.95% |
| 08/30 | 1,576 | 1,588 | 1,552 | 1,566 | -0.19% | 83,800 | 889億7086万 | +2.09% |
| 08/29 | 1,550 | 1,583 | 1,542 | 1,569 | +1.16% | 65,600 | 891億4131万 | +2.42% |
| 08/28 | 1,537 | 1,574 | 1,535 | 1,551 | +0.91% | 62,500 | 881億1865万 | +1.57% |
| 08/27 | 1,522 | 1,547 | 1,517 | 1,537 | +0.52% | 37,500 | 873億2326万 | +0.79% |
| 08/24 | 1,522 | 1,534 | 1,514 | 1,529 | +1.53% | 26,500 | 868億6874万 | +0.46% |
| 08/23 | 1,507 | 1,517 | 1,501 | 1,506 | -0.33% | 37,200 | 855億6202万 | -0.86% |
| 08/22 | 1,481 | 1,527 | 1,474 | 1,511 | +1.75% | 71,300 | 858億4609万 | -0.46% |
| 08/21 | 1,466 | 1,491 | 1,465 | 1,485 | +0.2% | 47,500 | 843億6892万 | -2.11% |
| 08/20 | 1,487 | 1,514 | 1,474 | 1,482 | -1.2% | 55,800 | 841億9848万 | -2.31% |
| 08/17 | 1,479 | 1,506 | 1,479 | 1,500 | +2.32% | 41,000 | 852億2113万 | -0.92% |
| 08/16 | 1,486 | 1,501 | 1,463 | 1,466 | -2.66% | 64,400 | 832億8946万 | -2.98% |
| 08/15 | 1,519 | 1,523 | 1,495 | 1,506 | -1.18% | 51,500 | 855億6202万 | -0.13% |
| 08/14 | 1,500 | 1,524 | 1,500 | 1,524 | +1.8% | 39,300 | 865億8467万 | +1.26% |
| 08/13 | 1,531 | 1,537 | 1,490 | 1,497 | -3.17% | 61,800 | 850億5069万 | -0.27% |
| 08/10 | 1,562 | 1,582 | 1,541 | 1,546 | -1.02% | 57,700 | 878億3458万 | +3.27% |
| 08/09 | 1,562 | 1,568 | 1,545 | 1,562 | 0% | 41,100 | 887億4361万 | +4.76% |
| 08/08 | 1,576 | 1,589 | 1,560 | 1,562 | -0.57% | 86,900 | 887億4361万 | +5.19% |
| 08/07 | 1,556 | 1,574 | 1,547 | 1,571 | +0.77% | 56,400 | 892億5494万 | +6.22% |
| 08/06 | 1,549 | 1,570 | 1,542 | 1,559 | +0.65% | 53,800 | 885億7317万 | +5.77% |
| 08/03 | 1,576 | 1,576 | 1,533 | 1,549 | -1.34% | 116,200 | 880億503万 | +5.23% |
| 08/02 | （自社株買い）取締役会(2018年6月14日)での決議状況(取得期間2018年6月15日～2018年7月20日) |
| 08/02 | 1,616 | 1,627 | 1,563 | 1,570 | -2.73% | 116,700 | 891億9812万 | +6.95% |
| 08/01 | 1,600 | 1,670 | 1,560 | 1,614 | +5.49% | 289,700 | 916億9794万 | +10.17% |
| 07/31 | （IR情報）15:00 2019年3月期第1四半期決算短信〔日本基準〕(連結) |
| 07/31 | （IR情報）15:00 腰椎椎間板ヘルニア治療剤「ヘルニコア椎間板注用1.25単位」の新発売について |
| 07/31 | 1,543 | 1,553 | 1,504 | 1,530 | 0% | 159,500 | 869億2556万 | +4.72% |
| 07/30 | 1,535 | 1,543 | 1,508 | 1,530 | +0.86% | 90,600 | 869億2556万 | +4.87% |
| 07/27 | 1,530 | 1,530 | 1,501 | 1,517 | -0.98% | 74,400 | 861億8697万 | +3.98% |
| 07/26 | 1,469 | 1,536 | 1,466 | 1,532 | +5.87% | 155,600 | 870億3919万 | +4.93% |
| 07/25 | （IR情報）15:00 平成30年7月豪雨災害に対する支援のお知らせ |
| 07/25 | 1,488 | 1,491 | 1,443 | 1,447 | -2.76% | 163,700 | 822億999万 | -0.96% |
| 07/24 | 1,489 | 1,495 | 1,469 | 1,488 | +1.64% | 83,600 | 845億3937万 | +1.64% |
| 07/23 | 1,460 | 1,481 | 1,460 | 1,464 | +0.21% | 78,500 | 831億7583万 | -0.2% |
| 07/20 | 1,469 | 1,477 | 1,453 | 1,461 | -0.34% | 48,200 | 830億538万 | -0.68% |
| 07/19 | 1,500 | 1,500 | 1,464 | 1,466 | -1.68% | 60,300 | 832億8946万 | -0.68% |
| 07/18 | 1,496 | 1,496 | 1,478 | 1,491 | +0.81% | 87,700 | 847億981万 | +0.74% |
| 07/17 | 1,417 | 1,482 | 1,413 | 1,479 | +4.08% | 129,700 | 840億2804万 | -0.34% |
| 07/13 | 1,429 | 1,439 | 1,417 | 1,421 | +0.35% | 74,200 | 807億3282万 | -4.44% |
| 07/12 | 1,414 | 1,436 | 1,414 | 1,416 | +0.43% | 74,500 | 804億4875万 | -5.16% |
| 07/11 | 1,416 | 1,416 | 1,395 | 1,410 | -0.56% | 86,000 | 801億787万 | -5.94% |
| 07/10 | 1,438 | 1,448 | 1,418 | 1,418 | -0.63% | 116,100 | 805億6238万 | -5.78% |
| 07/09 | 1,385 | 1,427 | 1,385 | 1,427 | +2.74% | 75,700 | 810億7371万 | -5.5% |
| 07/06 | 1,390 | 1,400 | 1,383 | 1,389 | -0.29% | 135,400 | 789億1477万 | -8.32% |
| 07/05 | （IR情報）10:00 自己株式の取得結果及び取得終了に関するお知らせ |
| 07/05 | 1,426 | 1,428 | 1,391 | 1,393 | -2.18% | 100,000 | 791億4203万 | -8.54% |
| 07/04 | 1,416 | 1,428 | 1,402 | 1,424 | +0.21% | 93,500 | 809億326万 | -6.87% |
| 07/03 | （自社株買い）取締役会(2018年6月14日)での決議状況(取得期間2018年6月15日～2018年7月20日) |
| 07/03 | 1,444 | 1,449 | 1,417 | 1,421 | -1.59% | 135,100 | 807億3282万 | -7.31% |
| 07/02 | （IR情報）10:00 自己株式の取得状況に関するお知らせ |
| 07/02 | 1,487 | 1,490 | 1,442 | 1,444 | -2.89% | 155,300 | 820億3955万 | -6.11% |
| 06/29 | 1,458 | 1,499 | 1,434 | 1,487 | +1.92% | 143,100 | 844億8255万 | -3.69% |
| 06/28 | 1,499 | 1,506 | 1,445 | 1,459 | -2.8% | 195,900 | 828億9176万 | -5.75% |
| 06/27 | 1,490 | 1,510 | 1,488 | 1,501 | +0.13% | 71,200 | 852億7795万 | -3.41% |
| 06/26 | 1,481 | 1,501 | 1,478 | 1,499 | +0.6% | 68,600 | 851億6432万 | -3.85% |
| 06/25 | 1,532 | 1,534 | 1,487 | 1,490 | -2.42% | 120,100 | 846億5299万 | -4.73% |
| 06/22 | 1,544 | 1,551 | 1,520 | 1,527 | -1.1% | 160,700 | 867億5512万 | -2.74% |
| 06/21 | 1,550 | 1,567 | 1,543 | 1,544 | -0.39% | 111,700 | 877億2095万 | -1.91% |
| 06/20 | 1,520 | 1,553 | 1,508 | 1,550 | +1.51% | 142,400 | 880億6184万 | -1.77% |
| 06/19 | 1,560 | 1,560 | 1,523 | 1,527 | -2.49% | 105,900 | 867億5512万 | -3.35% |
| 06/18 | 1,575 | 1,586 | 1,561 | 1,566 | -0.25% | 108,000 | 889億7086万 | -1.51% |
| 06/15 | 1,601 | 1,608 | 1,570 | 1,570 | -0.44% | 166,400 | 891億9812万 | -1.69% |
| 06/14 | （IR情報）17:00 自己株式取得に係る事項の決定に関するお知らせ |
| 06/14 | （IR情報）17:00 組織変更に関するお知らせ |
| 06/14 | 1,585 | 1,600 | 1,574 | 1,577 | -0.32% | 78,300 | 895億9582万 | -1.81% |
| 06/13 | 1,577 | 1,593 | 1,571 | 1,582 | +0.7% | 61,200 | 898億7989万 | -2.04% |
| 06/12 | 1,560 | 1,575 | 1,560 | 1,571 | +0.96% | 55,000 | 892億5494万 | -3.26% |
| 06/11 | 1,584 | 1,589 | 1,556 | 1,556 | -1.71% | 65,500 | 884億272万 | -4.83% |
| 06/08 | 1,567 | 1,593 | 1,567 | 1,583 | +1.02% | 109,600 | 899億3670万 | -3.83% |
| 06/07 | 1,544 | 1,569 | 1,541 | 1,567 | +1.49% | 68,000 | 890億2768万 | -5.26% |
| 06/06 | 1,550 | 1,550 | 1,532 | 1,544 | -0.71% | 74,000 | 877億2095万 | -7.16% |
| 06/05 | 1,567 | 1,568 | 1,542 | 1,555 | -0.38% | 90,900 | 883億4591万 | -7.11% |
| 06/04 | 1,579 | 1,579 | 1,551 | 1,561 | -0.51% | 83,700 | 886億8679万 | -7.36% |
| 06/01 | 1,541 | 1,583 | 1,541 | 1,569 | +1.69% | 137,700 | 891億4131万 | -7.49% |
| 05/31 | 1,540 | 1,546 | 1,528 | 1,543 | +0.59% | 125,900 | 876億6414万 | -9.55% |
| 05/30 | 1,540 | 1,548 | 1,530 | 1,534 | -1.22% | 132,500 | 871億5281万 | -10.71% |
| 05/29 | 1,575 | 1,580 | 1,551 | 1,553 | -1.4% | 93,800 | 882億3228万 | -10.28% |
| 05/28 | 1,600 | 1,602 | 1,571 | 1,575 | -1.56% | 106,900 | 894億8219万 | -9.69% |
| 05/25 | 1,607 | 1,620 | 1,598 | 1,600 | -0.44% | 102,900 | 909億254万 | -8.88% |
| 05/24 | 1,629 | 1,644 | 1,603 | 1,607 | -1.35% | 150,900 | 913億24万 | -9.05% |
| 05/23 | 1,618 | 1,636 | 1,612 | 1,629 | +0.49% | 114,600 | 925億5015万 | -8.38% |
| 05/22 | （IR情報）10:00 腰椎椎間板ヘルニア治療剤「ヘルニコア椎間板注用1.25単位」の国内における薬価基準収載及び発売時期に関するお知らせ |
| 05/22 | 1,630 | 1,630 | 1,604 | 1,621 | -0.86% | 189,900 | 920億9564万 | -9.34% |
| 05/21 | （IR情報）10:00 癒着防止材SI-449の臨床試験開始に関するお知らせ |
| 05/21 | 1,635 | 1,654 | 1,628 | 1,635 | +0.25% | 138,800 | 928億9104万 | -9.17% |
| 05/18 | 1,635 | 1,641 | 1,611 | 1,631 | -0.67% | 125,400 | 926億6378万 | -9.94% |
| 05/17 | 1,615 | 1,650 | 1,602 | 1,642 | +1.8% | 203,500 | 932億8874万 | -10.03% |
| 05/16 | 1,769 | 1,769 | 1,594 | 1,613 | -9.02% | 533,700 | 916億4113万 | -12.34% |
| 05/15 | 1,745 | 1,787 | 1,744 | 1,773 | +2.13% | 139,500 | 1007億3138万 | -4.37% |
| 05/14 | 1,627 | 1,769 | 1,627 | 1,736 | -3.5% | 277,000 | 986億2926万 | -6.67% |
| 05/11 | （IR情報）16:00 2018年3月期決算短信〔日本基準〕(連結) |
| 05/11 | 1,772 | 1,800 | 1,754 | 1,799 | +0.67% | 138,100 | 1022億855万 | -3.69% |
| 05/10 | 1,800 | 1,806 | 1,781 | 1,787 | -0.94% | 69,200 | 1015億2678万 | -4.59% |
| 05/09 | 1,850 | 1,850 | 1,793 | 1,804 | -2.49% | 147,100 | 1024億9262万 | -4.04% |
| 05/08 | 1,835 | 1,865 | 1,835 | 1,850 | +0.82% | 96,200 | 1051億607万 | -1.86% |
| 05/07 | 1,793 | 1,843 | 1,782 | 1,835 | +2.17% | 111,900 | 1042億5386万 | -2.86% |
