| 2024 |
| 07/26 | 221 | 233 | 221 | 231 | +3.13% | 238,800 | 93億1030万 | -3.75% |
| 07/25 | 225 | 227 | 222 | 224 | -0.88% | 273,100 | 90億2817万 | -6.28% |
| 07/24 | 229 | 233 | 225 | 226 | -1.31% | 721,200 | 91億878万 | -5.44% |
| 07/24 | （空売り報告）UBS AG 370,400株（0.91%）-0.12% |
| 07/23 | （5%ルール）auカブコム証券（0.14%）三菱UFJキャピタル(組合名)三菱UFJキャピタル4（6.71%） |
| 07/23 | 231 | 236 | 228 | 229 | -0.43% | 308,500 | 92億2970万 | -4.18% |
| 07/22 | 241 | 241 | 229 | 230 | -6.12% | 706,500 | 92億7000万 | -3.36% |
| 07/22 | （空売り報告）UBS AG 416,400株（1.03%）+0.14% |
| 07/19 | 255 | 255 | 244 | 245 | -3.16% | 658,300 | 98億7456万 | +2.94% |
| 07/19 | （空売り報告）UBS AG 361,600株（0.89%）+0.12% |
| 07/18 | （IR情報）15:00 ストック・オプションとしての新株予約権の発行に関するお知らせ |
| 07/18 | 254 | 261 | 251 | 253 | +0.4% | 996,700 | 101億9700万 | +6.75% |
| 07/18 | （空売り報告）Jefferies International Limited 438,100株（1.08%）+0.44% |
| 07/18 | （空売り報告）UBS AG 311,600株（0.77%）-0.05% |
| 07/17 | 246 | 260 | 244 | 252 | +2.44% | 997,500 | 101億5670万 | +7.23% |
| 07/17 | （空売り報告）Jefferies International Limited 258,100株（0.64%）+0.05% |
| 07/17 | （空売り報告）UBS AG 333,200株（0.82%）-0.17% |
| 07/16 | 243 | 254 | 243 | 246 | +1.23% | 510,400 | 99億1487万 | +5.13% |
| 07/16 | （空売り報告）UBS AG 399,100株（0.99%）-0.12% |
| 07/12 | （IR情報）15:00 2025年2月期第1四半期決算短信〔日本基準〕(非連結) |
| 07/12 | 249 | 251 | 242 | 243 | -4.33% | 792,300 | 97億9396万 | +4.29% |
| 07/11 | （5%ルール）auカブコム証券（0.11%）三菱UFJキャピタル(組合名)三菱UFJキャピタル4（6.95%） |
| 07/11 | 239 | 260 | 239 | 254 | +6.72% | 1,779,200 | 102億3730万 | +9.96% |
| 07/11 | （空売り報告）UBS AG 448,000株（1.11%）-0.23% |
| 07/11 | （空売り報告）MERRILL LYNCH INTERNATIONAL 138,800株（0.34%）-0.17%義務消失 |
| 07/11 | （空売り報告）Barclays Capital Securities Ltd 135,100株（0.33%）-0.35%義務消失 |
| 07/10 | 237 | 239 | 230 | 238 | 0% | 411,000 | 95億9243万 | +3.93% |
| 07/10 | （空売り報告）MERRILL LYNCH INTERNATIONAL 206,600株（0.51%）+0.01% |
| 07/09 | 234 | 241 | 232 | 238 | +2.15% | 520,100 | 95億9243万 | +4.39% |
| 07/09 | （空売り報告）UBS AG 543,000株（1.34%）-0.12% |
| 07/08 | 228 | 238 | 226 | 233 | +3.1% | 1,172,300 | 93億9091万 | +2.19% |
| 07/08 | （空売り報告）UBS AG 588,700株（1.46%）-0.05% |
| 07/08 | （空売り報告）MERRILL LYNCH INTERNATIONAL 205,200株（0.5%）-0.01% |
| 07/08 | （空売り報告）Barclays Capital Securities Ltd 276,600株（0.68%）-0.02% |
| 07/05 | 240 | 242 | 224 | 226 | -7.38% | 2,071,400 | 91億878万 | -0.44% |
| 07/05 | （空売り報告）XTX Markets Pte Ltd 126,400株（0.31%）-0.37%義務消失 |
| 07/05 | （空売り報告）UBS AG 612,100株（1.51%）+0.72% |
| 07/05 | （空売り報告）MERRILL LYNCH INTERNATIONAL 207,500株（0.51%）再IN |
| 07/05 | （空売り報告）Barclays Capital Securities Ltd 283,500株（0.7%）+0.1% |
| 07/04 | 284 | 293 | 244 | 244 | +2.95% | 9,284,600 | 98億3426万 | +7.96% |
| 07/04 | （空売り報告）XTX Markets Pte Ltd 274,400株（0.68%）再IN |
| 07/04 | （空売り報告）UBS AG 321,100株（0.79%）+0.18% |
| 07/04 | （空売り報告）Barclays Capital Securities Ltd 242,500株（0.6%）再IN |
| 07/03 | （IR情報）15:00 脊髄損傷に対する新規治療薬候補の導入における北海道大学との独占的実施許諾契約締結に関するお知らせ |
| 07/03 | 246 | 248 | 234 | 237 | -3.27% | 491,100 | 95億5213万 | +5.33% |
| 07/03 | （空売り報告）Barclays Capital Securities Ltd 199,100株（0.49%）-0.03%義務消失 |
| 07/02 | 250 | 257 | 245 | 245 | -1.61% | 316,300 | 98億7456万 | +8.89% |
| 07/01 | 257 | 258 | 248 | 249 | -1.58% | 433,800 | 100億3578万 | +11.16% |
| 06/28 | 257 | 261 | 244 | 253 | -0.39% | 649,300 | 101億9700万 | +13.45% |
| 06/28 | （空売り報告）UBS AG 247,700株（0.61%）+0.03% |
| 06/27 | 239 | 257 | 237 | 254 | +6.28% | 715,800 | 102億3730万 | +14.41% |
| 06/27 | （空売り報告）UBS AG 236,300株（0.58%）-0.09% |
| 06/27 | （空売り報告）Barclays Capital Securities Ltd 211,700株（0.52%）再IN |
| 06/26 | 235 | 240 | 231 | 239 | +1.7% | 224,800 | 96億3274万 | +8.14% |
| 06/25 | 240 | 250 | 235 | 235 | -0.84% | 712,000 | 94億7152万 | +6.33% |
| 06/25 | （空売り報告）UBS AG 272,800株（0.67%）+0.08% |
| 06/24 | 234 | 238 | 229 | 237 | +1.28% | 407,900 | 95億5213万 | +7.24% |
| 06/21 | 220 | 236 | 220 | 234 | +4.93% | 540,700 | 94億3122万 | +5.41% |
| 06/20 | 219 | 231 | 215 | 223 | +4.69% | 830,900 | 89億8787万 | +0.45% |
| 06/19 | （IR情報）15:00 TMS-008の第I相臨床試験における最初の被験者への投与のお知らせ |
| 06/19 | 219 | 222 | 210 | 213 | -3.18% | 304,400 | 85億8483万 | -4.05% |
| 06/18 | 213 | 226 | 209 | 220 | +3.77% | 452,500 | 88億6696万 | -1.79% |
| 06/17 | 216 | 216 | 208 | 212 | -3.2% | 303,400 | 85億4452万 | -5.36% |
| 06/14 | 216 | 222 | 211 | 219 | -0.9% | 237,900 | 88億2665万 | -3.1% |
| 06/13 | 218 | 228 | 218 | 221 | +1.84% | 205,900 | 89億726万 | -2.64% |
| 06/12 | （IR情報）15:00 個人投資家向けIRセミナー登壇のお知らせ |
| 06/12 | （5%ルール）三菱UFJキャピタル(組合名)三菱UFJキャピタル4（9%）auカブコム証券（0.15%） |
| 06/12 | 229 | 230 | 217 | 217 | -2.25% | 495,600 | 87億4604万 | -4.82% |
| 06/11 | 213 | 224 | 208 | 222 | +5.21% | 719,600 | 89億4756万 | -3.48% |
| 06/10 | 204 | 212 | 204 | 211 | +3.94% | 289,100 | 85億422万 | -8.66% |
| 06/10 | （空売り報告）UBS AG 240,900株（0.59%）-0.06% |
| 06/07 | 208 | 209 | 200 | 203 | -2.4% | 302,800 | 81億8178万 | -12.88% |
| 06/06 | 214 | 219 | 208 | 208 | -3.26% | 292,300 | 83億8330万 | -11.49% |
| 06/06 | （空売り報告）Barclays Capital Securities Ltd 199,500株（0.49%）-0.01%義務消失 |
| 06/05 | 220 | 221 | 215 | 215 | -1.83% | 244,400 | 86億6543万 | -8.9% |
| 06/05 | （空売り報告）Barclays Capital Securities Ltd 201,600株（0.5%）再IN |
| 06/04 | 208 | 222 | 207 | 219 | +4.29% | 284,200 | 88億2665万 | -7.59% |
| 06/04 | （空売り報告）UBS AG 262,100株（0.65%）-0.14% |
| 06/04 | （空売り報告）Barclays Capital Securities Ltd 200,600株（0.49%）-0.08%義務消失 |
| 06/03 | 214 | 215 | 206 | 210 | 0% | 339,500 | 84億6391万 | -11.76% |
| 05/31 | 226 | 231 | 196 | 210 | -7.89% | 1,539,100 | 84億6391万 | -12.13% |
| 05/30 | 217 | 235 | 216 | 228 | +3.64% | 242,900 | 91億8939万 | -5% |
| 05/30 | （空売り報告）XTX Markets Pte Ltd 196,300株（0.48%）-0.04%義務消失 |
| 05/29 | （IR情報）15:00 事業計画及び成長可能性に関する事項 |
| 05/29 | 233 | 233 | 220 | 220 | -4.76% | 134,900 | 88億6696万 | -8.71% |
| 05/29 | （空売り報告）XTX Markets Pte Ltd 213,300株（0.52%）再IN |
| 05/29 | （空売り報告）Barclays Capital Securities Ltd 232,100株（0.57%）再IN |
| 05/28 | 232 | 236 | 228 | 231 | 0% | 96,900 | 93億1030万 | -4.15% |
| 05/27 | 231 | 232 | 223 | 231 | +1.32% | 157,300 | 93億1030万 | -4.55% |
| 05/27 | （空売り報告）UBS AG 322,300株（0.79%）-0.09% |
| 05/24 | 227 | 228 | 221 | 228 | -0.87% | 212,900 | 91億8939万 | -6.17% |
| 05/24 | （空売り報告）XTX Markets Pte Ltd 201,400株（0.49%）-0.04%義務消失 |
| 05/23 | 235 | 235 | 228 | 230 | -1.71% | 103,300 | 92億7000万 | -5.74% |
| 05/22 | 240 | 240 | 233 | 234 | -2.09% | 106,300 | 94億3122万 | -4.49% |
| 05/22 | （空売り報告）XTX Markets Pte Ltd 214,300株（0.53%）再IN |
| 05/21 | 239 | 240 | 237 | 239 | -0.42% | 85,700 | 96億3274万 | -2.85% |
| 05/20 | 240 | 246 | 239 | 240 | +0.42% | 77,400 | 96億7304万 | -2.44% |
| 05/17 | 239 | 243 | 237 | 239 | -0.42% | 131,200 | 96億3274万 | -3.24% |
| 05/16 | 242 | 242 | 236 | 240 | -0.83% | 126,100 | 96億7304万 | -3.23% |
| 05/16 | （空売り報告）XTX Markets Pte Ltd 200,800株（0.49%）-0.03%義務消失 |
| 05/15 | 246 | 246 | 238 | 242 | -0.41% | 114,000 | 97億5365万 | -2.42% |
| 05/14 | 238 | 255 | 235 | 243 | +1.67% | 227,900 | 97億9396万 | -2.41% |
| 05/14 | （空売り報告）UBS AG 356,700株（0.88%）-0.02% |
| 05/14 | （空売り報告）MERRILL LYNCH INTERNATIONAL 191,800株（0.47%）-0.05%義務消失 |
| 05/13 | 245 | 245 | 239 | 239 | -2.45% | 130,100 | 96億3274万 | -4.4% |
| 05/10 | 253 | 254 | 245 | 245 | -2.78% | 170,500 | 98億7456万 | -2.39% |
| 05/10 | （空売り報告）MERRILL LYNCH INTERNATIONAL 211,100株（0.52%）-0.01% |
| 05/09 | 256 | 259 | 248 | 252 | -2.7% | 199,100 | 101億5670万 | 0% |
| 05/09 | （空売り報告）MERRILL LYNCH INTERNATIONAL 214,000株（0.53%）+0.02% |
| 05/08 | 256 | 261 | 254 | 259 | +1.97% | 379,300 | 104億3883万 | +2.78% |
| 05/08 | （IR情報）9:00 SMTP化合物関連特許(日本)に関するお知らせ |
| 05/08 | （空売り報告）Jefferies International Limited 238,800株（0.59%）新規 |
| 05/08 | （空売り報告）MERRILL LYNCH INTERNATIONAL 206,600株（0.51%）+0.01% |
| 05/07 | 259 | 260 | 251 | 254 | -0.78% | 197,300 | 102億3730万 | +0.4% |
| 05/07 | （空売り報告）MERRILL LYNCH INTERNATIONAL 202,700株（0.5%）再IN |
| 05/02 | 258 | 265 | 252 | 256 | -1.16% | 260,100 | 103億1791万 | +0.79% |
| 05/02 | （空売り報告）UBS AG 365,400株（0.9%）+0.01% |
| 05/01 | 246 | 262 | 243 | 259 | +5.28% | 256,300 | 104億3883万 | +1.57% |
| 05/01 | （空売り報告）XTX Markets Pte Ltd 213,400株（0.52%）再IN |
| 05/01 | （空売り報告）UBS AG 362,200株（0.89%）-0.07% |
| 04/30 | 240 | 246 | 236 | 246 | +4.24% | 110,800 | 99億1487万 | -3.91% |
| 04/26 | 238 | 241 | 232 | 236 | -0.42% | 133,900 | 95億1183万 | -8.53% |
| 04/26 | （空売り報告）XTX Markets Pte Ltd 199,900株（0.49%）-0.06%義務消失 |
| 04/26 | （空売り報告）MERRILL LYNCH INTERNATIONAL 193,600株（0.48%）-0.02%義務消失 |
| 04/25 | 242 | 245 | 237 | 237 | -3.66% | 194,400 | 95億5213万 | -9.2% |
| 04/25 | （空売り報告）MERRILL LYNCH INTERNATIONAL 205,200株（0.5%）-0.04% |
| 04/24 | 236 | 246 | 236 | 246 | +4.24% | 172,800 | 99億1487万 | -6.46% |
| 04/24 | （空売り報告）MERRILL LYNCH INTERNATIONAL 221,100株（0.54%）-0.03% |
| 04/23 | 240 | 248 | 234 | 236 | +1.72% | 440,800 | 95億1183万 | -10.94% |
| 04/23 | （空売り報告）MERRILL LYNCH INTERNATIONAL 231,600株（0.57%）+0.03% |
| 04/22 | 233 | 234 | 229 | 232 | -0.43% | 280,000 | 93億5061万 | -13.11% |
| 04/22 | （空売り報告）UBS AG 390,000株（0.96%）-0.09% |
| 04/22 | （空売り報告）MERRILL LYNCH INTERNATIONAL 221,200株（0.54%）-0.08% |
| 04/19 | 249 | 250 | 223 | 233 | -7.91% | 780,900 | 93億9091万 | -13.38% |
| 04/19 | （空売り報告）UBS AG 425,700株（1.05%）-0.14% |
| 04/18 | 250 | 258 | 247 | 253 | +1.61% | 237,200 | 101億9700万 | -6.64% |
| 04/18 | （空売り報告）MERRILL LYNCH INTERNATIONAL 251,200株（0.62%）+0.03% |
| 04/17 | （IR情報）15:00 2024年2月期決算説明資料 |
| 04/17 | 257 | 260 | 249 | 249 | -4.23% | 236,700 | 100億3578万 | -8.79% |
| 04/17 | （空売り報告）MERRILL LYNCH INTERNATIONAL 239,500株（0.59%）+0.03% |
| 04/16 | 260 | 261 | 256 | 260 | +1.56% | 204,200 | 104億7913万 | -5.45% |
| 04/16 | （空売り報告）MERRILL LYNCH INTERNATIONAL 225,800株（0.56%）+0.04% |
| 04/15 | 243 | 262 | 243 | 256 | +3.23% | 500,600 | 103億1791万 | -7.25% |
| 04/15 | （空売り報告）UBS AG 481,800株（1.19%）-0.16% |
| 04/15 | （空売り報告）MERRILL LYNCH INTERNATIONAL 211,700株（0.52%）-0.05% |
| 04/12 | （IR情報）15:00 2024年2月期決算短信〔日本基準〕(非連結) |
| 04/12 | （IR情報）15:00 個別業績の前年実績との差異に関するお知らせ |
| 04/12 | 259 | 259 | 248 | 248 | -2.75% | 296,000 | 99億9548万 | -10.79% |
| 04/12 | （空売り報告）UBS AG 544,300株（1.35%）+0.06% |
| 04/12 | （空売り報告）MERRILL LYNCH INTERNATIONAL 231,800株（0.57%）再IN |
| 04/11 | 255 | 255 | 247 | 255 | +0.39% | 299,200 | 102億7761万 | -8.93% |
| 04/10 | 258 | 262 | 251 | 254 | -1.55% | 286,600 | 102億3730万 | -10.25% |
| 04/09 | 260 | 266 | 258 | 258 | -0.39% | 206,300 | 103億9852万 | -9.47% |
| 04/08 | 269 | 269 | 259 | 259 | -3% | 155,300 | 104億3883万 | -10.07% |
| 04/05 | （5%ルール）ニッセイ・キャピタル（7.29%） |
| 04/05 | 263 | 267 | 257 | 267 | +0.38% | 171,700 | 107億6126万 | -7.93% |
| 04/05 | （空売り報告）UBS AG 522,800株（1.29%）-0.09% |
| 04/04 | 263 | 269 | 256 | 266 | +4.31% | 280,000 | 107億2096万 | -8.9% |
| 04/03 | 259 | 263 | 254 | 255 | -3.77% | 352,900 | 102億7761万 | -13.56% |
| 04/03 | （空売り報告）UBS AG 559,400株（1.38%）-0.08% |
| 04/02 | 273 | 273 | 260 | 265 | -2.57% | 473,800 | 106億8065万 | -11.07% |
| 04/02 | （空売り報告）UBS AG 588,500株（1.46%）-0.11% |
| 04/01 | 278 | 280 | 271 | 272 | -3.2% | 311,600 | 109億6278万 | -9.33% |
| 03/29 | 277 | 282 | 276 | 281 | +1.44% | 157,700 | 113億2552万 | -6.64% |
| 03/28 | 287 | 287 | 275 | 277 | -2.46% | 260,500 | 111億6430万 | -7.97% |
| 03/27 | 284 | 287 | 270 | 284 | -0.35% | 425,200 | 114億4644万 | -5.96% |
| 03/26 | 293 | 296 | 285 | 285 | -2.4% | 358,200 | 114億8674万 | -5.63% |
| 03/26 | （空売り報告）XTX Markets Pte Ltd 225,600株（0.55%）再IN |
| 03/25 | 291 | 298 | 290 | 292 | -1.02% | 262,100 | 117億6887万 | -2.99% |
| 03/22 | 299 | 300 | 291 | 295 | -1.67% | 406,300 | 118億8978万 | -1.67% |
| 03/21 | 296 | 304 | 294 | 300 | +1.35% | 365,600 | 120億9131万 | 0% |
| 03/21 | （空売り報告）UBS AG 634,100株（1.57%）-0.12% |
| 03/19 | 294 | 296 | 288 | 296 | +0.68% | 300,800 | 119億3009万 | -1% |
| 03/18 | 283 | 298 | 283 | 294 | +6.14% | 547,000 | 118億4948万 | -1.67% |
| 03/18 | （空売り報告）UBS AG 682,000株（1.69%）-0.07% |
| 03/15 | 280 | 285 | 275 | 277 | -2.46% | 315,600 | 111億6430万 | -7.67% |
| 03/14 | 286 | 294 | 274 | 284 | -1.73% | 633,500 | 114億4644万 | -5.65% |
| 03/14 | （空売り報告）UBS AG 711,300株（1.76%）-0.04% |
| 03/13 | 299 | 300 | 287 | 289 | -3.67% | 470,500 | 116億4796万 | -3.67% |
| 03/13 | （空売り報告）UBS AG 727,100株（1.8%）+0.18% |
| 03/12 | 292 | 301 | 288 | 300 | +1.01% | 405,100 | 120億9131万 | +0.33% |
| 03/11 | 292 | 301 | 290 | 297 | -1% | 580,100 | 119億7039万 | -0.34% |
| 03/08 | 293 | 309 | 286 | 300 | 0% | 1,040,700 | 120億9131万 | +0.67% |
| 03/07 | （5%ルール）ニッセイ・キャピタル（8.44%） |
| 03/07 | 322 | 325 | 299 | 300 | -7.12% | 1,333,600 | 120億9131万 | +1.01% |
| 03/06 | 316 | 323 | 312 | 323 | +1.89% | 659,900 | 130億1831万 | +8.75% |
| 03/06 | （空売り報告）XTX Markets Pte Ltd 156,500株（0.38%）-0.14%義務消失 |
| 03/05 | 312 | 322 | 305 | 317 | -0.63% | 1,119,400 | 127億7648万 | +7.82% |
| 03/05 | （空売り報告）XTX Markets Pte Ltd 210,600株（0.52%）-0.08% |
| 03/05 | （空売り報告）UBS AG 656,300株（1.62%）+0.05% |
| 03/04 | 315 | 328 | 310 | 319 | +1.59% | 1,178,600 | 128億5709万 | +8.87% |
| 03/04 | （空売り報告）XTX Markets Pte Ltd 243,600株（0.6%）-0.11% |
| 03/04 | （空売り報告）UBS AG 636,600株（1.57%）-0.4% |
| 03/04 | （空売り報告）Nomura International plc 169,300株（0.42%）-0.09%義務消失 |
| 03/01 | （空売り報告）XTX Markets Pte Ltd 287,800株（0.71%）再IN |
| 03/01 | （空売り報告）UBS AG 795,700株（1.97%）+0.36% |
| 03/01 | （空売り報告）Nomura International plc 206,500株（0.51%）再IN |
| 02/29 | （IR情報）16:45 TMS-008の国内第1相臨床試験における治験計画届出書提出のお知らせ |
| 02/29 | （空売り報告）UBS AG 652,900株（1.61%）+0.03% |
| 02/29 | （空売り報告）モルガン・スタンレーMUFG証券 197,500株（0.49%）-0.04%義務消失 |
| 02/28 | （空売り報告）UBS AG 639,600株（1.58%）+0.11% |
| 02/27 | （空売り報告）XTX Markets Pte Ltd 104,900株（0.26%）-0.3%義務消失 |
| 02/27 | （空売り報告）UBS AG 593,900株（1.47%）+0.32% |
| 02/27 | （空売り報告）モルガン・スタンレーMUFG証券 215,400株（0.53%）-0.14% |
